ClinVar Discovery Rate Comparison
Cumulative P/LP submissions normalized by disease prevalence
Subs / Prevalence
Cystic Fibrosis (CFTR)
Fabry Disease (GLA)
FDA Approval Timeline
When each treatment was approved — earlier approvals may correlate with longer diagnostic incentive
ClinVar Submitter Overlap
Labs that submit P/LP variants to ClinVar for both diseases
Key Takeaways
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